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Crospovidone

1-Ethenyl-2-pyrrolidinone homopolymer Cross-linked povidone XLPVP

Crospovidone
Crospovidone is a water-insoluble synthetic cross-linked homopolymer. It is used as a tablet disintegrant in the direct compression or wet - and dry-granulation process. Crospovidone is white to creamy-white, finely divided, free-flowing, practically tasteless, hygroscopic powder. Larger particles provide faster disintegration than smaller particles.
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Crospovidone
Crospovidone
Primary function
Disintegrant
Typical use level
Tablet disintegrant used at 2 - 5% concentration in tablets prepared by direct compression or wet and dry granulation methods
Physical data

  • Appearance: white to creamy-white hygroscopic powder
  • Density: 1.22 g/cm³
  • Flowability: Free-flowing
  • Solubility: Practically insoluble in water

Benefits / Claims
High capillary activity and hydration capacity with little tendency to form gels
Can be used intra- and extra-granularly for improved active release
pH independent disintegrant performance for active delivery throughout the GIT
Suitable for
Tablet
Hard Gel Capsules
ODT
Buccal
Chewable

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