Crystallisation inhibitor
Crystallisation of drug reduces the bioavailability of the drug resulting in reduction of efficacy of formulation. Crystallisation inhibitors prevent the crystallisation of the drug by increasing viscosity or by formation of hydrogen bonds with the drug.
Examples: Povidone grades, Copovidone grades
Examples: Povidone grades, Copovidone grades
Crystallisation inhibitor
| Crystallisation inhibitor | |
|---|---|
| Primary function | Crystallisation inhibitor |
| Typical use level | For softgel capsules, up to 10% w/w can be explored. |
| Benefits / Claims | Help solubilizing the drug thus inhibiting further crystal growth |
| Suitable for | |