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Low-substituted Hydroxypropyl Cellulose

Cellulose, 2-hydroxypropyl ether (low-substituted) L-HPC

Low-substituted Hydroxypropyl Cellulose
L-HPC is a low-substituted hydroxypropyl ether of cellulose. It is used in orally disintegrating tablets as disintegrant and/or binder. Special grades have been developed specifically for ODT applications.
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Low-substituted Hydroxypropyl Cellulose
Low-substituted Hydroxypropyl Cellulose
Primary function
Disintegrant, binder and diluent
Typical use level
5 - 20% (depending on grade selection and/or application)
Physical data

  • Appearance: white to yellowish white hygroscopic powder or granules
  • Tasteless
  • Insoluble in water
  • Bulk density: 0.28 - 0.48 g/cm³
  • Degree of substitution: 8 - 14%

Benefits / Claims
Specialize L-HPC grades have been developed to enhance ODT robustness and enhancing hydration to reduce disintegration times.
Suitable for
Tablet
Hard Gel Capsules
ODT
Buccal
Chewable

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