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Poloxamers

a-Hydro-co-hydroxypoly(oxyethylene)poly (oxypropylene) poly (oxyethylene) block copolymer

Poloxamers
Non-ionic polyoxyethylene-polyoxypropylene copolymers used as emulsifiers, solubilizing agents and gelling agents. All poloxamers are chemically similar in composition, differing only in the amounts of propylene oxide and ethylene oxide added during manufacturing. The Polyoxyethylene segment imparts hydrophilicity, while he polyoxypropylene segment imparts hydrophobicity. Poloxamers 188, 407, and 338 are thermoresponsive polymers

Solids: Poloxamer 188, Poloxamer 338, Poloxamer 407
Liquid: Poloxamer 124
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Poloxamers
Poloxamers
Primary function
Surfactant
Typical use level
Wetting agent - 0.01 - 5% Stabilizing agent - 1 - 5% Emulsifier - 0.3 - 1%
Physical data
HLB values:

  • Poloxamer 124: 12 - 18
  • Poloxamer 188, 338: > 24
  • Poloxamer 407: 18 - 23
  • Oxyethylene content (%):
  • Poloxamer 124: 44.8 - 48.6%
  • Poloxamer 188: 79.9 - 83.7%
  • Poloxamer 338: 81.4 - 84.9%
  • Poloxamer 407: 71.5 - 74.9%

Benefits / Claims
Possesses low critical micelle concentration (CMC) stabilizing and solubilizing occurring at concentrations 1 to 2 orders of magnitude lower than for standard ethoxylated surfactants.
Suitable for
Cream/ Emulsion
Gel
Softgel capsules

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