Stabiliser
In topical formulations like creams, lotions and gels, stabilisers can be antioxidants and chelating agents. The stabilisers are added to the formulation to prevent or minimize degradation of sensitive API. In softgel capsules, stabilisers help prevent or minimize sticking, tacking, softening and premature dissolution of the capsule shell. They also minimise oxidation or degradation of the active ingredient fill or gelatin shell.
Antioxidants for softgel capsules
Chelating agent for softgel capsules
Antioxidants for softgel capsules
- Tocopherols (Vitamin E)
Butylated hydroxytoluene
Hydroquinone and tertbutyl hydroquinone
Dithiothreitol
Thiourea
Sodium thiosulphate
Thioglycolic acid
Acetyl cysteine
Chelating agent for softgel capsules
- Edetate Sodium
Edetate Disodium
Edetate Calcium Disodium
Sodium hexametaphosphate
8-hydroxyquinoline
Phytic acid
Stabiliser
Stabiliser | |
---|---|
Primary function | Stabiliser |
Typical use level | Preferable use range: 0.01 - 1% w/w |
Benefits / Claims | Prevent or minimize degradation of sensitive API in the formulation |
Suitable for | |